Friday, November 24, 2017 Current Time : 21:41 In Tehran

New antimicrobial graphene based coatings for biomaterial implants

 

PhD position is available in the research group of Dr. Ismaeil Haririan at the TUMS School of Pharmacy, Tehran, Iran (http://pharmacyen.tums.ac.ir/en/page/19520/About) and is funded by Iran National Science and National Elite Foundations. We seek to appoint an ambitious and self-motivated PhD student with interest in Material Chemistry, Molecular Biology or Pharmacy.

 

Job Description:

 

The project deals with the implant infection which is the major complication of the use of biomaterials implants. Treatment of such infections is difficult and often requiring removal of the device. Antimicrobial coatings are considered a most promising solution, as they entrapped an infectious biofilm between a destructive surface (coating) and the host immune system or antibiotic treatment as an unfriendly body environment. Most importantly, the influence of antimicrobial coatings on biofilm formation should be examined using evaluation methods for directly antimicrobial and immunocompatible coatings, indispensable for development of the other coatings. Although the current evaluation methods remain useful for studying effects of single factors applied on a biomaterials surface but, evaluating combined effects of antimicrobial coatings, systemic antibiotics and the host immune system requires developing novel methods and tools that overcome these limitations and applying these new methods in situ.

 

The project will be focused on the development of new antimicrobial graphene based coatings also development of improved methods for evaluating antimicrobial and immunocompatible coatings in vitro and in vivo. These methods will be made available for application toward the newly developed coatings. In order to monitor the efficacy of the coatings, novel nanosensors will be used as a tool for monitoring and evaluating combined effects of antimicrobial coatings, systemic antibiotics and the host immune system.

 

The research will involve several different disciplines spanning from nanoparticle physico-chemical characterization to quantitative host-pathogen interactions studies, with methods such as flow cytometry, and fluorescence imaging. Proteomics will be used in combination with cell biology and molecular biology approaches to characterize and identify the mechanisms involved.

 

Qualifications and skills:

 

The successful candidate for this PhD position will have the following qualifications:

  • A high honors masters' degree in Material Chemistry, Biology, Biomedical Sciences, Pharmacy or related areas
  • Very good knowledge of written and spoken English and very good communication skills
  • Enthusiasm for research in an interdisciplinary setting and international environment
  • Good communication skills to be able to act as an excellent team player
  • Previous experience or particular interest in microbiology, cell culture systems, cell biology and/or with nanoparticles would be considered an asset, as also previous experience with biocompatibility of coatings, immunoblotting and proteomic to study cellular processes.

 

 

Application:

 

Applications for the position should include in 1 file the following information:

 

  • Short curriculum vitae with details master degree(s); this should include the list of courses attended and transcript(s) of grades, and a short description of previous research experience (such as the master research project)
  • Motivation letter (max 1 page)
  • Name and (email) address of two professional references

 

If your profile matches the above description, please send your CV, motivation letter and contact details of two referees in a single pdf file, by email to sm-daghighi@razi.tums.ac.ir.

 

For further information please contact:

Mojtaba Dghighi, e-mail: sm-daghighi@razi.tums.ac.ir

 

 

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